Chronic Fatigue




  • 1 in 2 of those with chronic fatigue syndrome may experience other physical symptoms
  • 4 in 5 chronic fatigue syndrome patients are female

Chronic Fatigue Syndrome

Chronic fatigue syndrome (CFS) is a debilitating chronic illness that affects multiple body systems and is characterized by mental and physical fatigue that can seriously impact daily living and self-care. Over 1 million people in America may suffer from chronic fatigue syndrome, and many have yet to be diagnosed or seek appropriate care.

  • Less than 1 in 5 CFS sufferers has been diagnosed.

  • Over 4 in 5 CFS patients are female.

  • Up to 1 in 2 CFS cases may experience other physical symptoms.

  • Up to 2 in 5 of those with CFS may have chemical sensitivities.

Though there is no known cause, evidence suggests that those with CFS may have impaired energy metabolism. CFS sufferers may also have altered metabolic detoxification function, which is the body's natural process of filtering potentially hazardous compounds that are inhaled, digested, or absorbed by skin (e.g., heavy metals, food chemicals). Food intolerances and environmental sensitivities, which are commonly reported in CFS, may increase symptom severity or frequency.

Metagenics offers specialized programs that include a clinically developed medical food and a dietary plan formulated to support metabolic detoxification. These programs are designed to provide adequate fuel for both cleansing and other daily activities, providing energy and support for overall well-being.

UltraClear Plus®

Servings Per Container:  21 (By weight)

UltraClear Plus® is a medical food formulated to provide enhanced, specialized nutritional support for patients with chronic fatigue syndrome, and includes macro- and micronutrients to address altered energetic function and liver detoxification. Designed for patients who may benefit from additional support for liver function, this formula features glycine and L-cysteine to help support Phase II liver detoxification. Green tea catechins and mixed carotenoids are added to provide antioxidant protection against potentially harmful compounds generated during the natural liver detoxification process. Provided in a low-allergenic-potential rice protein concentrate baseaEU"which may be beneficial during times of increased detoxification burdenaEU"this formula provides well-rounded nutritional support.

  • Designed to support healthy Phase I and Phase II detoxification function.

  • Supports balanced detoxification capacity.

UltraClear®

Servings Per Container: 21

UltraClear® is a medical food formulated to provide specialized nutritional support to address altered energetic and liver detoxification function in patients with chronic fatigue syndrome. Designed for those patients who may benefit from specialized nutritional support for liver function, this formula features a low-allergenic-potential rice protein base, which may be beneficial during times of increased toxin exposure. Enhanced with specific nutrients and antioxidants that support detoxification and energetic processes, this medical food provides well-rounded nutritional support.

  • Addresses altered energetic function.

  • Provides nutrients that support hepatic detoxification processes.

  • May be used on a long-term basis.

  • Supplies low-allergy-potential rice protein concentrate with added limiting essential amino acids L-lysine and L-threonine to increase the biological value of the protein.

  • Rich in the antioxidant vitamins A, C, E, and beta-carotene, which may help protect against oxygen free radicals generated during the hepatic detoxification process.

UltraClear® Plus pH

Servings Per Container: 21 (by weight)

UltraClear® Plus pH is a medical food formulated to provide enhanced, specialized nutritional support for patients with chronic fatigue syndrome, and includes macro- and micronutrients to address altered energetic function and liver detoxification. Featuring potassium citrate and sesame, this formula helps to promote alkalinization and support Phase II liver detoxification function. UltraClear Plus pH also provides glycine and magnesium sulfate to support Phase II detoxification activities, as well as green tea catechins and mixed carotenoids to provide antioxidant protection against potentially harmful compounds generated during the natural detoxification process. Provided in a low-allergenic-potential rice protein concentrate baseaEU"which may be beneficial during times of increased detoxification burdenaEU"this formula provides well-rounded nutritional support.

In addition to the benefits provided by UltraClear Plus:

  • Delivers extra support for Phase I and Phase II activity.

  • Promotes an alkaline urinary pH status and Phase II detoxification activity.


FAQ  UltraClear PLUS® Medical Food

Q. How does UltraClear PLUS® Medical Food
compare to other products or approaches?

A. Unlike some approaches, this medical food
program provides a science-based protocol to help
address underlying factors that may increase
symptoms in chemically sensitive individuals. The
body's natural detoxification process demands
energy, so it relies on macronutrients (protein,
carbs, fats) and other micronutrients that may be
missing in some products or dietary recommenda-
tions. This formula contains a scientifically designed
blend of targeted nutrients--including quality rice
protein, carbohydrates, and fats--to support energy
metabolism and complex activities in both phases of
the body's detoxification process. UltraClear PLUS
differs from UltraClear(r) Medical Food in that it
provides additional support for second phase
activities that prepare dietary and other toxins for
elimination. This formula contains only natural
ingredients for a safer approach, and has been
clinically reviewed at the FMRC.

Q. How does UltraClear PLUS® Medical Food work?

A. This product provides nutrients that support
energetic and liver detoxification function. Science-
based metabolic detoxification programs are often
recommended as a first approach to help relieve
complaints such as fatigue, cloudy thinking, and
mood changes. Think of it as cleaning out the
environmental "junk" that may be affecting your
health. UltraClear Plus provides research-based
nutritional support for liver function, which may be
beneficial during times of increased toxin exposure.
It's enhanced with specific nutrients--including rice
protein developed through a patented manufacturing process--and antioxidants that support energy metabolism and detoxification function, particularly
in the second phase. Rice protein has a lower
allergenic potential than many common animal or
vegetable protein sources, which (along with careful
formulation and manufacturing) helps make this
product suitable for dietary elimination programs.
This product is recommended for use with a
modified elimination diet that reduces dietary
chemical exposure.

Q. How long is UltraClear PLUS® Medical Food
typically recommended?

A. A typical introductory program is 28 days
(including a modified elimination diet) to evaluate
progress, though a 10-day regimen or other
protocol may be recommended. Some people report
positive changes in just a few weeks, but results may
vary. In some individuals, eliminating common
dietary chemicals may also create some short-term
symptoms, such as caffeine withdrawal, that are not
associated with product use. This product may also
be recommended for long-term support. For best
results, follow your health care professional's
guidelines.

Q. Who would benefit from UltraClear PLUS® Medical
Food?

A. People whose quality of life is affected by low
energy or lingering tiredness associated with
chronic fatigue syndrome--and have altered
energetic or liver detoxification function (clearance
of dietary and other chemicals) due to genetic
predisposition, a history of chronic nutrient
insufficiency, and/or "environmental overload" that
that can lead to a buildup of stored toxins. UltraClear
PLUS was designed for chronic fatigue syndrome
patient who may benefit from added nutritional
support for the second phase of the body's natural
detoxification process.

Q. Why is UltraClear PLUS® Medical Food safe?

A. Medical foods must contain ingredients that are
generally regarded as safe (GRAS) or FDA approved,
and Metagenics continually evaluates formula
ingredients in concert with current nutritional
research for optimal safety and effectiveness. Plus,
Metagenics' manufacturing facility has 3 certifications
for good manufacturing practices to ensure the
highest quality. (This product is suitable for those
who may be sensitive to lactose or soy.)

FAQ  UltraClear®

Q.
How does UltraClear® Medical Food compare to
other products or approaches?

A. Unlike some approaches, this medical food program
provides a science-based protocol to help address
underlying factors that may increase symptoms in
chronic fatigue syndrome patients who are chemically
sensitive. The body's natural detoxification process
demands energy, so it relies on macronutrients
(protein, carbs, fats) and other nutrients that may be
missing in some products or dietary recommendations.
This formula contains a scientifically designed blend of
targeted nutrients--including quality rice protein,
carbs, and fats--to support energy metabolism and
balanced activities in both phases of the body's
detoxification process. This product contains only
natural ingredients for a safer approach, and has been
clinically reviewed at the FMRC.

Q. How does UltraClear® Medical Food work?

A. This product provides nutrients that support
energetic and liver detoxification function. Science-
based metabolic detoxification programs are often
recommended as a first approach to help relieve
complaints such as fatigue, cloudy thinking, and mood
changes. Think of it as cleaning out the environmental
"junk" that may be affecting your health. UltraClear
provides research-based nutritional support for liver
function, which may be beneficial during times of
increased toxin exposure. It's enhanced with specific
nutrients--including rice protein developed through a
patented manufacturing process--and antioxidants
that support detoxification function and energy
metabolism. Rice protein has a lower allergenic
potential than many common animal or vegetable
protein sources, which (along with careful formulation
and manufacturing) helps make this product suitable
for dietary elimination programs. This product is
recommended for use with a modified elimination
diet that reduces dietary chemical exposure.

Q. How long is UltraClear® Medical Food typically
recommended?

A. A typical introductory program is 28 days (including
a modified elimination diet) to evaluate progress,
though a 10-day regimen or other protocol may be
recommended. Some people report positive changes
in just a few weeks, but results may vary. In some
individuals, eliminating common dietary chemicals
may also create some short-term symptoms, such as
caffeine withdrawal, that are not associated with
product use. This product may also be recommended
for long-term support. For best results, follow your
health care professional's guidelines.

Q. Who would benefit from UltraClear® Medical Food?

A. People whose quality of life is affected by low energy
or lingering tiredness associated with chronic fatigue
syndrome--and have altered energetic or liver
detoxification function (clearance of dietary and other
chemicals) due to genetic predisposition, a history of
chronic nutrient insufficiency, and/or "environmental
overload" that can lead to a buildup of stored toxins.

Q. Why is UltraClear® Medical Food safe?

A. Medical foods must contain ingredients that are
generally regarded as safe (GRAS) or FDA approved,
and Metagenics continually evaluates formula
ingredients in concert with current nutritional research
for optimal safety and effectiveness. Plus, Metagenics'
manufacturing facility has 3 certifications for good
manufacturing practices to ensure the highest quality.
(This product is suitable for those who may be sensitive
to lactose or soy. )

FAQ  UltraClear® Plus pH

Q. How does UltraClear® Plus pH Medical Food
compare to other products or approaches?

A. Unlike some approaches, this medical food program
provides a science-based protocol to help address
underlying factors that may increase symptoms in
chemically sensitive individuals. The body's natural
detoxification process demands energy, so it relies on
macronutrients (protein, carbs, fats) and other
micronutrients that may be missing in some products
or dietary recommendations. This formula contains a
scientifically designed blend of nutrients--including
quality protein, carbs, and fats--to support energy
metabolism and complex activities in both phases of
the body's detoxification process. This unique formula
provides additional nutritional support for second
phase activities along with alkalizing nutrients to
promote a balanced pH--both of which enhance
excretion of toxins. This formula contains only
natural ingredients for a safer approach, and has been
clinically reviewed at the FMRC.

Q. How does UltraClear® Plus pH Medical Food work?

A. This product provides nutrients that support
energetic and liver detoxification function, as well as a
healthy urinary pH level. Science-based metabolic
detoxification programs are often recommended as a
first approach to help relieve complaints such as
fatigue, cloudy thinking, and mood changes. Think of
it as cleaning out the environmental "junk" that may
be affecting your health. Like UltraClear PLUS(r)
Medical Food, this formula offers targeted nutrients to
support energy metabolism, as well as enhanced
nutritional support for activities related to the second
phase of detoxification (when the body prepares
toxins for elimination). In addition, it provides
potassium citrate to promote balanced pH levels and
further support toxin clearance. The rice protein base
has a lower allergenic potential than many common
animal or vegetable protein sources, which (along with
careful formulation and manufacturing) helps make this
product suitable for dietary elimination programs.
This product is recommended for use with a modified
elimination diet that reduces dietary chemical exposure.

Q. How long is UltraClear® Plus pH Medical Food
typically recommended?

A. A typical introductory program is 28 days (including
a modified elimination diet) to evaluate progress,
though a 10-day regimen or other protocol may be
recommended. Some people report positive changes in
just a few weeks, but results may vary. In some
individuals, eliminating common dietary chemicals may
also create some short-term symptoms, such as
caffeine withdrawal, that are not associated with
product use. This product may also be recommended
for long-term support. For best results, follow your
health care professional's guidelines.

Q. Who would benefit from UltraClear® Plus pH
Medical Food?

A. People whose quality of life is affected by low
energy or lingering tiredness associated with chronic
fatigue syndrome--and have altered energetic or liver
detoxification function. This formula is targeted to
those who have an elevated toxic burden and a low
alkaline (acidic) urinary pH level (below 6.6), which can
negatively influence the kidneys' ability to eliminate
dietary and environmental toxins. This is common in
people with compromised detoxification activity, as
well as in those who eat a diet high in acid-producing
animal proteins with lower consumption of fruits and
vegetables. Your pH level can quickly be determined
with an easy, noninvasive test in a health care
professional's office.

Q. Why is UltraClear® Plus pH Medical Food safe?

A. Medical foods must contain ingredients that are
generally regarded as safe (GRAS) or FDA approved,
and Metagenics continually evaluates formula
ingredients in concert with current nutritional research
for optimal safety and effectiveness. Plus, Metagenics'
manufacturing facility has 3 certifications for good
manufacturing practices to ensure the highest quality.
(This product is suitable for those who may be
sensitive to lactose or soy.)

Ingredients  UltraClear PLUS® Medical Food

Serving Size: About 2 scoops (44 g)

Ingredient

Amount

Daily Value

Calories

160 

 

Fat

3 g 

 

Saturated Fat†

1 g 

 

Trans Fat

0 g 

 

Cholesterol

0 mg 

 

Sodium

70 mg 

 

Potassium

420 mg 

 

Carbohydrate

19 g 

 

Dietary Fiber

2 g 

 

Sugars

6 g 

 

Protein

15 g 

 

Vitamin A (retinyl palmitate)

1000 IU 

20% 

Vitamin A (beta-carotene)

4000 IU 

80% 

Vitamin C

300 mg 

500% 

Calcium

200 mg 

20% 

Iron

0.5 mg 

2% 

Vitamin D

35 IU 

8% 

Vitamin E

42 IU 

140% 

Thiamin

2 mg 

130% 

Riboflavin

2 mg 

120% 

Niacin

7 mg 

35% 

Vitamin B6

3.4 mg 

170% 

Folic acid

80 mcg 

20% 

Vitamin B12

3.6 mcg 

60% 

Biotin

135 mcg 

45% 

Pantothenic Acid

36 mg 

360% 

Phosphorus

250 mg 

25% 

Iodine

53 mcg 

35% 

Magnesium

200 mg 

50% 

Zinc

10 mg 

70% 

Copper

1 mg 

50% 

Manganese

1 mg 

50% 

Chromium

50 mcg 

40% 

L-Glycine

1600 mg 

L-Glutamine

100 mg 

L-Cysteine

85 mg 

L-Lysine

505 mg 

L-Alanine

235 mg 

L-Threonine

285 mg 

DL-Methionine

170 mg 

Sulfate (as magnesium sulfate)

20 mg 

Catechins (from decaffeinated green tea extract)

15 mg 

Other Ingredients: Rice protein concentrate, rice syrup solids, magnesium citrate, L-glycine, natural flavors, dipotassium phosphate, olive oil, medium-chain triglycerides, calcium citrate, L-lysine HCl, ascorbic acid, L-threonine, L-alanine, DL-methionine, silica, dicalcium phosphate, L-cysteine HCl, L-glutamine, zinc gluconate, d-alpha tocopheryl acetate, D-calcium pantothenate, magnesium sulfate, vitamin A (beta-carotene, retinyl palmitate), decaffeinated green tea extract, niacinamide, copper gluconate, pyridoxine HCl, thiamin HCl, riboflavin, chromium polynicotinate, biotin, folic acid, potassium iodide, cyanocobalamin, and cholecalciferol.
Directions: Blend, shake, or briskly stir 2 level scoops of UltraClear Plus into
8 ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4 to 5 ounces of chilled water or juice twice daily during the first 3 to 4 days before starting a full daily dose.
Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.
Formulated to Exclude: Wheat, gluten, soy, dairy products, egg, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and artificial flavors. This product is Gluten Free.
Do not use if safety seal is missing or broken.
ChromeMate® is a registered trademark of InterHealth, Inc.

Ingredients  UltraClear®

Serving Size: 2 Scoops (44 g)

Ingredient

Amount

Daily Value

Calories

170 

 

Fat

4 g 

 

Saturated Fat†

1.5 g 

 

Trans Fat

0 g 

 

Cholesterol

0 mg 

 

Sodium

60 mg 

 

Potassium

420 mg 

 

Carbohydrate

19 g 

 

Dietary Fiber

2 g 

 

Sugars

6 g 

 

Protein

15 g 

 

Vitamin A (retinyl palmitate)

1000 IU 

20% 

Vitamin A (beta-carotene)

4000 IU 

80% 

Vitamin C

110 mg 

180% 

Calcium

130 mg 

15% 

Iron

3.6 mg 

20% 

Vitamin D

35 IU 

8% 

Vitamin E

80 IU 

270% 

Thiamin

2 mg 

130% 

Riboflavin

2 mg 

120% 

Niacin

7 mg 

35% 

Vitamin B6

3.4 mg 

170% 

Folic acid

80 mcg 

20% 

Vitamin B12

3.6 mcg 

60% 

Biotin

135 mcg 

45% 

Pantothenic Acid

3.5 mg 

35% 

Phosphorus

200 mg 

20% 

Iodine

53 mcg 

35% 

Magnesium

140 mg 

35% 

Zinc

10 mg 

70% 

Copper

1 mg 

50% 

Manganese

1.3 mg 

70% 

Chromium

50 mcg 

40% 

L-Glycine

100 mg 

L-Glutamine

100 mg 

L-Cysteine

30 mg 

L-Lysine

35 mg 

L-Threonine

35 mg 

DL-Methionine

50 mg 

Other Ingredients: Rice protein concentrate, rice syrup solids, magnesium citrate, olive oil, medium chain triglycerides, natural flavors, dipotassium phosphate, silica, d-alpha tocopheryl acetate, dicalcium phosphate, ascorbic acid, calcium citrate, L-glutamine, L-glycine, zinc gluconate, DL-methionine, L-lysine HCl, L-cysteine HCl, L-threonine, ferrous fumarate, niacinamide, copper gluconate, pyridoxine HCl, D-calcium pantothenate, thiamin HCl, beta-carotene, riboflavin, chromium polynicotinate, retinyl palmitate, biotin, folic acid, potassium iodide, cyanocobalamin, and cholecalciferol.
Directions: Blend, shake, or briskly stir 2 level scoops (44 grams) of UltraClear into 8 ounces of chilled water or juice twice daily, or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4 to 5 ounces of chilled water or juice twice daily during the first 3 to 4 days before starting a full daily dose.
Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.
Formulated to Exclude: Wheat, gluten, soy protein, egg, dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and artificial flavors.
This product is Gluten Free.
Do not use if safety seal is missing or broken.
Contents sold by weight, not volume. Some settling may occur during shipping and handling.
†Range of 1,400 mg-1575 mg



Ingredients  UltraClear® Plus pH

Serving Size: About 2 scoops (46 g)

Ingredient

Amount

Daily Value

Calories

180 

 

Fat

5 g 

 

Saturated Fat†

1 g 

 

Trans Fat

0 g 

 

Cholesterol

0 mg 

 

Sodium

100 mg 

 

Potassium

750 mg 

 

Carbohydrate

19 g 

 

Dietary Fiber

2 g 

 

Sugars

6 g 

 

Protein

15 g 

 

Vitamin A (retinyl palmitate)

1000 IU 

20% 

Vitamin A (beta-carotene)

4000 IU 

80% 

Vitamin C

300 mg 

500% 

Calcium

210 mg 

20% 

Iron

0.5 mg 

2% 

Vitamin D

35 IU 

8% 

Vitamin E

42 IU 

140% 

Thiamin

2 mg 

130% 

Riboflavin

2 mg 

120% 

Niacin

7 mg 

35% 

Vitamin B6

3.4 mg 

170% 

Folic acid

80 mcg 

20% 

Vitamin B12

3.6 mcg 

60% 

Biotin

135 mcg 

45% 

Pantothenic Acid

36 mg 

360% 

Phosphorus

300 mg 

30% 

Iodine

53 mcg 

35% 

Magnesium

230 mg 

60% 

Zinc

10 mg 

70% 

Copper

1 mg 

50% 

Manganese

1 mg 

50% 

Chromium

50 mcg 

40% 

L-Glycine

1600 mg 

L-Glutamine

100 mg 

L-Cysteine

85 mg 

L-Lysine

505 mg 

L-Alanine

235 mg 

L-Threonine

285 mg 

DL-Methionine

170 mg 

Sulfate (as magnesium sulfate)

20 mg 

Catechins (from decaffeinated green tea extract)

15 mg 

Other Ingredients: Rice protein concentrate, rice syrup solids, sesame seed oil, magnesium citrate, L-glycine, potassium citrate, natural flavors, dipotassium phosphate, medium-chain triglycerides, calcium citrate, L-lysine HCl, silica, ascorbic acid, L-threonine, L-alanine, DL-methionine, dicalcium phosphate, L-cysteine HCl, L-glutamine, zinc gluconate, d-alpha tocopheryl acetate, D-calcium pantothenate, magnesium sulfate, vitamin A (beta-carotene, retinyl palmitate), decaffeinated green tea extract, niacinamide, copper gluconate, pyridoxine HCl, thiamin HCl, riboflavin, chromium polynicotinate, biotin, folic acid, potassium iodide, cyanocobalamin, and cholecalciferol.
Directions: Blend, shake, or briskly stir about 2 level scoops of UltraClear Plus pH into 8 ounces of chilled water or juice twice daily, or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4 to 5 ounces of chilled water or juice twice daily during the first 3 to 4 days before starting a full daily dose.
Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.
Caution: Do not use if you are pregnant or nursing, you have hyperkalemia or abnormal kidney function, you are taking ACE inhibitors, angiotensin receptor blockers (ARBs), or potassium sparing diuretics. If taking other medication, consult your healthcare practitioner before use.
Formulated to Exclude: Wheat, gluten, soy, dairy products, egg, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and artificial flavors. This product is Gluten Free.
Do not use if safety seal is missing or broken.
U.S. Patent #7,029,703