• 3 in 5 fibromyalgia sufferers may have increased symptoms after certain environmental chemical exposures
  • 9 out of 10 fibromyalgia cases are women


Fibromyalga is characterized by chronic, widespread pain and/or stiffness in the muscles, ligaments, and tendons. Patients may also report fatigue and other symptoms that can seriously affect daily living. Scientific literature suggests that there may be multiple causes for these symptoms. That's why no single approach to date offers reliable relief for a majority of patients.

An increasing amount of research also suggests that environmental influences may either trigger or exacerbate debilitating symptoms associated with musculoskeletal pain syndromes. Toxin exposure can result in prolonged firing of the body's pain receptors, increasing sensitization and exaggerating the central nervous system response. And exposure to the heavy metal mercury may contribute to altered inflammatory and immune responses and have neurotoxic effects.

  • Up to 3 in 5 fibromyalgia sufferers my have increased symptoms after certain environmental chemical exposures.

  • Fibromyalgia is one of the most common chronic pain syndromes, affecting 10 million Americans.

  • As many as 9 out of 10 fibromyalgia cases are women.

Metagenics offers a specialized program for fibromyalgia patient's that includes clinically designed dietary plan and medical food formulated to support the body's natural removal of toxins, such as heavy metals.

Note: Medical Foods are to be used under the direct supervision of a physician or other healthcare practitioner.


UltraClear RENEW™ is a medical food formulated to provide specialized nutritional support to help address altered pain signaling and neuromuscular function in patients with fibromyalgia. UltraClear RENEW is designed for individuals who may benefit from additional support for detoxification function, and features an array of nutrients in a low-allergen-potential rice protein base to support Phase II liver detoxification. In preliminary research with a small number of fibromyalgia patients with dental amalgams, administration of UltraClear RENEW was associated with significant decreases in FIQ (Fibromyalgia Impact Questionnaire) scores, including pain and stiffness.

  • Helps to address altered pain signaling.

  • Designed to support healthy Phase I and Phase II liver detoxification function.

  • Supports healthy neuromuscular function.


Serving Size: About 2 scoops (37 g)



Daily Value




Total Fat

3 g 


Saturated Fat†

1 g 


Trans Fat

0 g 



0 mg 



220 mg 



520 mg 



20 g 


Dietary Fiber

3 g 



9 g 



12 g 


Vitamin A (as beta-carotene)

4000 IU 


Vitamin A (as retinyl palmitate)

1000 IU 


Vitamin C

300 mg 



150 mg 



1 mg 


Vitamin D

35 IU 


Vitamin E

42 IU 



2 mg 



2 mg 



7 mg 


Vitamin B6

3.4 mg 


Folic acid

80 mcg 


Vitamin B12

3.6 mcg 



135 mcg 


Pantothenic Acid

36 mg 



230 mg 



53 mcg 



160 mg 



10 mg 



1 mg 



1 mg 



50 mcg 



460 mg 


Proprietary Spent Hops (Humulus lupulus) Powder

1000 mg 


800 mg 


350 mg 


250 mg 


140 mg 


135 mg 

Prune (Prunus domestica) Skin Extract

125 mg 


125 mg 


100 mg 


100 mg 

Watercress (Nasturtium officinale) Whole Plant Extract

67 mg 

Ellagic Acid [from pomegranate (Punica granatum) Whole Fruit Extract]

50 mg 

Sulfate (magnesium sulfate)

20 mg 

Catechins (from decaffeinated green tea extract)

15 mg 

Other Ingredients: Rice protein concentrate,
rice syrup solids, fructose, natural flavors, magnesium citrate, proprietary spent hops powder (Humulus lupulus), partially hydrolyzed guar gum, dipotassium phosphate, olive oil, medium chain triglycerides, L-glycine, sodium chloride, calcium citrate, ascorbic acid, L-alanine, potassium citrate, L-threonine, magnesium chloride, L-lysine HCl, silica, DL-methionine, pomegranate extract, L-cysteine HCl, L-glutamine, prune skin extract, L-tyrosine, zinc gluconate, d-alpha tocopheryl acetate, watercress extract, decaffeinated green tea extract, D-calcium pantothenate, magnesium sulfate, vitamin A (beta-carotene, retinyl palmitate), niacinamide, copper gluconate, pyridoxine HCl
, thiamin HCl, riboflavin, chromium polynicotinate, biotin, folic acid, potassium iodide, cyanocobalamin, and cholecalciferol.

Directions: Blend, shake, or briskly stir about 2 level scoops (37 grams) of UltraClear RENEW into 8 ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4 to 5 ounces of chilled water or juice twice daily during the first 3 to 4 days before starting a full daily dose.

Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.

Caution: Do not use if pregnant or nursing. Not recommended for individuals taking anticoagulant medications.

Formulated to Exclude: Wheat, gluten, soy, dairy products, egg, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and artificial flavors.

This product is Gluten Free.

Do not use if safety seal is missing or broken.

†Range of 1,400 mg-1575 mg


Q.How does UltraClear RENEW™ Medical Food
compare to other products or approaches?

A.Unlike some approaches, this medical food
program provides a science-based protocol to
help address underlying factors that may increase
symptoms in chemically sensitive individuals.
It's the only medical food that specifically targets
pain signaling and neuromuscular function in
patients with fibromyalgia in a manner that does
not carry a risk of serious adverse events
associated with common target pathways to
relieve pain. This product contains only natural
ingredients for a safer approach with a
scientifically designed blend of targeted nutrients-
-including quality rice protein--to support energy
metabolism and balanced activities in both phases
of the body's detoxification process, particularly
the second phase.

Q.How does UltraClear RENEW™ Medical Food

A.This medical food provides nutrients that help
target underlying issues associated with
fibromyalgia, such as altered pain signaling and
neuromuscular function. Science-based metabolic
detoxification programs are often recommended
as a first approach to help clean out the
environmental "junk" that may be affecting your
health--or causing you pain. Some evidence
suggests that certain heavy metals, such as the
mercury in dental amalgam, may increase pain
and fatigue in those who are already chemically
sensitive. UltraClear RENEW is formulated to help
relieve pain and stiffness, and also provides
research-based nutrients to support important
detoxification activities, such as heavy metal
metabolism. The rice protein base has a lower
allergenic potential than many common protein
sources, which (along with careful formulation
and manufacturing) helps make this product
suitable for dietary elimination programs. This
product is recommended for use with a modified
elimination diet that reduces dietary chemical

Q.How long is UltraClear RENEW™ Medical Food
typically recommended?

A.In a 4-week preliminary study,** the UltraClear
RENEW program demonstrated significantly
decreased pain and stiffness, improved quality of
life, and increased mercury excretion. This
product may also be recommended for long-term
support. For best results, follow your health care
professional's guidelines. (** With UltraClear
RENEW and a modified elimination diet in a small
number of fibromyalgia patients with dental
amalgams conducted at the FMRC, after a 4-week
control phase with UltraClear MACRO(r) and the
Standard American Diet with seafood excluded.)

Q.Who would benefit from UltraClear RENEW™
Medical Food?

A.People whose quality of life is affected by
recurring, non-specific muscle pain and stiffness
associated with fibromyalgia, a condition
characterized by altered pain signaling and
neuromuscular function. This formula was
designed for individuals who may benefit from
additional support for detoxification function,
including heavy metabolism, which may be
influencing symptoms.

Q.Why is UltraClear RENEW™ Medical Food safe?

A.Medical foods must contain ingredients that
are generally regarded as safe (GRAS) or FDA
approved, and Metagenics continually evaluates
formula ingredients in concert with current
nutritional research for optimal safety and
effectiveness. Plus, Metagenics' manufacturing
facility has 3 certifications for good manufacturing practices to ensure the highest quality. (This product is not recommended for those taking anti-
coagulant medications. This product is suitable for
those who may be sensitive to lactose or soy. See
online catalog for complete allergen information.)