Premenstrual Syndrome


Premenstrual Syndrome

Premenstrual syndrome (PMS) includes symptoms associated with a woman's monthly menstrual cycle
a wide range of bothersome physical, mental, and emotional complaints that can vary in number and severity
by individual. These symptoms, which may seriously affect daily functioning, can begin up to several weeks
proper to menstruation and are often attributed to changes in hormone levels (e.g., estrogen) during a woman's cycle.

While no approach offers complete relief for everyone, some may benefit from nutritional support
for promoting healthy estrogen metabolism1. Simple lifestyle changes have also been shown to
help reduce or alleviate common PMS symptoms, which may be exacerbated by stress, unhealthy diets,
smoking and alcohol use.

  • PMS affects more than 85% of women at some point in their lives.
  • 3 in 4 menstruating women experience PMS symptoms.
  • Up to 2 in 5 women in the U.S. have symptoms that affect daily living.
  • During perimenopause, a woman may experience additional symptoms or an increase
  • in the severity or duration of her typical PMS symptoms.

Metagenics offers a specialized program that includes a clinically designed dietary plan,
lifestyle recommendations, and medical food2 formulated to relieve symptoms related to menstrual cycles.

  • 3 in 4 menstruating women experience
  • PMS symptoms
  • 2 in 5 women in the U.S. may
  • have symptoms that affect daily living
 1Metabolism: The physical and Chemical reactions the body's cells perform to convert food into the energy
for necessary functions throughout the body.

2Medical Food: Medical foods are formulated with macro and micro nutrients, in therapeutic amounts difficult
to obtain through dietary means, recognized by scientific principles to support the dietary management of a
disease or condition and administered by a licensed healthcare practitioner.
Estrium® Medical Food for PMS Nutritional Support for Symptoms Related to Premenstrual Syndrome

Estrium® is a medical food designed to provide specialized nutritional support for women with premenstrual syndrome. Estrium provides a specialized blend of macronutrients with all essential vitamins1 and minerals, along with non-soy phytoestrogens, antioxidants, and flaxseed hull (equal to approximately one tablespoon of whole flaxseed) that were specially selected for their ability to promote healthy estrogen metabolism and healthy hormone balance2.

  • Relieves symptoms related to menstrual cycles, such as
    • Abdominal discomfort
    • Occasional irritability
    • Feeling bloated
    • Minor back, joint, and muscle pain
    • Joint stiffness
    • Temporary weight gain
    • Breast tenderness
    • Feeling sad or blue
  • Modulates the effects of circulating estrogens with non-soy phytoestrogens from kudzu and flax.
  • Features a high quality, easily digestible rice protein concentrate.
  • Formulated with antioxidants, fiber, and a variety of well-researched ingredients.

 1 Vitamins are substances required by the body for normal functioning, growth, and development. There are 13 essential vitamins that must be obtained through dietary intake.

 2  Hormone balance, or healthy levels and ratios  

Frequently Asked Questions


How does Estrium® Medical Food compare to other products or approaches?


Lifestyle choices, such as unhealthy foods, may influence hormone metabolism and associated symptoms. Unlike some approaches, this medical food program provides non-soy phytoestrogens (from kudzu and flax) to promote hormone balance. And it was designed to complement dietary recommendations to help you achieve greater success. This product contains only natural ingredients for a safer approach, and has been clinically reviewed at the FMRC.


How does Estrium® Medical Food work?


This product provides research-based nutrients that support healthy estrogen metabolism and hormone cycles. It's enhanced with specific nutrients--including rice protein developed through a patented manufacturing process, phytoestrogens, antioxidants, and fiber--to support hormone balance. Rice protein has a lower allergenic potential than many common animal or vegetable protein sources. This product is recommended for use with a targeted eating plan to help nutritionally manage PMS symptoms.


How long is Estrium® Medical Food typically recommended?


The initial phase of the Estrium Program (with a targeted eating plan) is generally 8 weeks. Depending on your response, your health care professional may suggest that you continue on the program, continue Estrium or the diet alone, or use some other combination of diet and nutritional supplementation. It may also be advised that you take Estrium only in the second half of your menstrual cycle. For best results, follow your health care professional's guidelines.


Who would benefit from Estrium® Medical Food?


Women experiencing symptoms related to premenstrual syndrome (PMS) who may benefit from a medical food program to support hormone balance.


Why is Estrium® Medical Food safe?


Medical foods must contain ingredients that are generally regarded as safe (GRAS) or FDA approved, and Metagenics continually evaluates formula ingredients in concert with current nutritional research for optimal safety and effectiveness. Plus, Metagenics' manufacturing facility has 3 certifications for good manufacturing practices to ensure the highest quality. (This product is suitable for those who may be sensitive to lactose or soy. See online catalog for complete allergen information.)


Serving Size: About 2 Scoops (46 g)



Daily Value





4 g 


Saturated Fat

1 g 


Trans Fat

0 g 



0 mg 



50 mg 



300 mg 


Total Carbohydrate

22 g 


Dietary Fiber

3 g 



10 g 



15 g 


Vitamin A (retinyl palmitate)

1250 IU 


Vitamin A (as beta-carotene)

2500 IU 


Vitamin C

60 mg 



350 mg 



9 mg 


Vitamin D

40 IU 


Vitamin E

300 IU 



0.75 mg 



0.85 mg 



10 mg 


Vitamin B6

50 mg 


Folic Acid

400 mcg 


Vitamin B12

30 mcg 



150 mcg 


Pantothenic Acid

5 mg 



260 mg 



75 mcg 



240 mg 



7.5 mg 



1 mg 



1 mg 



100 mcg 



17.5 mg 


17.5 mg 

Isoflavones (from kudzu)

25 mg 

Flaxseed Hull (providing 70 mg of flax lignans)

1.84 g 


450 mg 

Turmeric Rhizome Extract (Curcuma longa) [standardized to 95% (200 mg) curcuminoids]

210 mg 

Other Ingredients: rice protein concentrate, rice syrup solids, fructose, olive oil, magnesium citrate, flaxseed hull, natural flavors, choline bitartrate (hydrogenated soybean oil encapsulate), calcium citrate, dipotassium phosphate, xanthan gum, d-alpha tocopheryl succinate, curcumin powder, guar gum, ascorbic acid, pyridoxine HCl, zinc gluconate, pueraria root extract, chromium polynicotinate, ferrous fumarate, L-lysine, L-threonine, niacinamide, copper gluconate, D-calcium pantothenate, beta-carotene, thiamin HCl, riboflavin, folic acid, retinyl palmitate, biotin, potassium iodide, cyanocobalamin, and cholecalciferol
Directions: Blend or shake about 2 level scoops (46 grams) of Estrium into 8 ounces of water, juice, or soy, almond, rice, or organic cow's milk twice daily, or as directed by your healthcare practitioner.
Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.
Warning: This product has been formulated to nutritionally support female patients who have symptoms associated with their hormone cycles. It has not been tested for interactions with oral contraceptive medications, and the effectiveness of oral contraceptives for birth control cannot be ensured during use of Estrium. Please discuss this important concern with your healthcare practitioner.
Formulated to Exclude: Wheat, egg, stimulants, dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and artificial flavors.
This product is Gluten Free.
Do not use if safety seal is missing or broken.
Contents sold by weight, not volume. Some settling may occur during shipping and handling. Serving size is measured by weight. A scoop is included for your convenience. The amount of product contained in two scoops may be above or below 45 grams due to variations in handling and product density.
Keep tightly closed in a cool, dry place.
†Range of 1,400 mg-1575 mg

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