Women's Health

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Women’s Health

Balance is the Key

At the heart of every woman’s health are her hormones, which are always in flux. Their ebb and flow influence all aspects of physical and emotional well-being. When a woman’s hormones are in balance, she feels healthy, energetic, and vital. Starting with puberty, each menstrual cycle orchestrates hormonal changes to prepare a woman for another stage in life. And as women age, gradual fluctuations through postmenopause may further influence virtually every aspect of health.

  • Over 4 in 5 menstruating women in the U.S. have at least 1 PMS symptom as part of their monthly cycle.
  • More than 7 in 10 women over 50 experience hot flashes.
  • 9 out of 10 women in the U.S. may not be getting enough calcium.
  • Over 6 in 10 American women do not take a daily multivitamin/mineral1 supplement.

Modern Lifestyles Disrupt Hormonal Ebb and Flow
Today’s demanding lifestyles put more stress on women’s bodies than they were designed to handle—and women often neglect to take care of themselves properly. The delicate, natural hormonal rhythms and balancing mechanisms are easily offset by factors such as poor nutrition, stress, and lack of sleep or exercise. To complicate matters, estrogen-mimicking chemicals in the environment and hormones in meat and dairy products can interfere with the balance of estrogens and estrogen metabolites. Many women are also faced with an imbalance in the way their hormones are excreted and renewed. These disruptions can cause vitality to diminish and contribute to long-term health concerns.

Nutritional Support for All Ages & Life Stages
Specialized support is often needed to compensate for modern lifestyles or to meet increased nutritional demands during certain female life stages such as pregnancy or menopause. Metagenics offers a complete line of women's nutritional formulas to promote healthy hormone balance2, vitality, and overall health.*

1Minerals are essential elements in the diet that are required for making hormones, regulating body functions such as your heartbeat, building bones, and are necessary for numerous enzymatic reactions.
2Hormone balance, or healthy levels and ratios of hormones, influence all aspects of physical and emotional well-being.

 

Wellness Essentials® Pregnancy

Advanced Nutritional
Support for
Preconception
through Nursing*

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Wellness Essentials®

Women

Advanced Nutritional Support for
Women

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Wellness Essentials® Women's Prime

Advanced Nutritional Support for
Menopause
and Beyond*

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 Estrovera™

Menopausal
Hot Flash Relief*
Featuring ERr 731™

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Estrium®

Nutritional Support
for Symptoms
Related to
Premenstrual Syndrome

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EstroFactors®

Promotes Estrogen
Balance, Relieves
Hormone-Related Symptoms*

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Ostera®

 

Promotes Healthy
Bone Remodeling
in Postmenopausal
Women*

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Meta I 3 C®

Estrogen-
Sensitive
Tissue
Support*

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Black Cohosh

Plus®

Relief for
Menopausal
Mood Changes*

Discover more...


Cal Apatite
 with
Magnesium

 

 EstroFactors®

Promotes Estrogen Balance, Relieves Hormone-Related Symptoms*

Servings Per Container: 90

EstroFactors® is designed to relieve mild mood swings, breast tenderness, cramping, and occasional sleeplessness associated with premenstrual syndrome and other estrogen-related issues. This unique formula features natural selective estrogen receptor modulators (SERMs) and L-5-methyltetrahydrofolate to support multiple aspects of estrogen metabolism.*

  • Designed to relieve common symptoms related to PMS, such as cramping, irritability, and breast tenderness.*

  • May support breast health by promoting the hydroxylation and methylation of estrogen.*

  • Provides natural selective estrogen receptor modulators (SERMs) to lessen the impact of the more potent forms of estrogen.*

  • Supplies L-5-methyltetrahydrofolate, providing an advantage for those with genetic variations in folate metabolism.*

Serving Size: 1 Tablet

Ingredient

Amount

Daily Value

Vitamin A (50% as Betatene® mixed carotenoids, 50% as retinyl palmitate)

833 IU 

17% 

Vitamin D (as cholecalciferol)

66.7 IU 

17% 

Vitamin E (as d-alpha tocopheryl succinate)

66.7 IU 

222% 

Vitamin K (as phytonadione)

13 mcg 

16% 

Vitamin B6 (as pyridoxine HCl)

16.7 mg 

835% 

Folate (as folic acid and calcium L-5-methyltetrahydrofolate†)

266 mcg 

67% 

Vitamin B12 (as methylcobalamin and cyanocobalamin)

10 mcg 

167% 

Isoflavones [from a proprietary blend of red clover (Trifolium pratense) flowering top extr

33 mg 

Turmeric (Curcuma longa) Rhizome Extract [standardized to 95% (66.7 mg) curcuminoids]

70 mg 

Rosemary (Rosmarinus officinalis) Leaf Extract [standardized to 11% min phenolic diterpenes

66.7 mg 

Resveratrol (from Polygonum cuspidatum root extract)

0.67 mg 

Trimethylglycine (as betaine HCl)

66.7 mg 

Chrysin

30 mg 


Other Ingredients: Microcrystalline cellulose, stearic acid (vegetable), calcium silicate, croscarmellose sodium, silica, magnesium stearate (vegetable), and coating (water, hypromellose, medium chain triglycerides, and hydroxypropylcellulose)

Directions: Take one tablet daily with a meal or as directed by your healthcare practitioner.

Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.

Caution: Not recommended for pregnant or nursing women. The effectiveness of oral contraceptives for birth control cannot be ensured while taking this product. If taking medication, consult your healthcare practitioner before use. Keep out of the reach of children.

Formulated to Exclude: Wheat, gluten, soy, dairy products, egg, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives.

This product is Gluten Free.

Keep tightly closed in a cool, dry place.

†Also known as special extract ERr 731 of Siberian rhubarb root.

 Meta I 3 C®

Estrogen-Sensitive Tissue Support*

Servings Per Container: 60

Meta I 3 C® is designed to promote healthy estrogen metabolism and balance by featuring indole-3-carbinol (I3C), a naturally occurring compound found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. Through its ability to promote the breakdown of estrogen to its beneficial, protective metabolite—2-hydroxyestrone—indole-3-carbinol may be a safe and effective way to help achieve beneficial balance in estrogen metabolism.

  • Helps promote the health of estrogen-sensitive tissues—such as those of the breast and cervix.*

  • Promotes the formation of “good,” protective 2-OH via its influence on hydroxylation pathways.*

  • Supports the detoxification of estrogens, and may also support healthy metabolism of other steroid hormones and xenoestrogens.*

  • Provides rosemary extract to reduce oxidation and help ensure potency.

  • Shelf-life evaluations guarantee stability.

Serving Size: 1 Capsule

Ingredient

Amount

Daily Value

Indole-3-Carbinol

150 mg 

Rosemary (Rosmarinus officinalis) Leaf Extract [standardized to 11% min phenolic diterpenes

50 mg 

Other Ingredients: Hydroxypropylmethylcellulose, maltodextrin, magnesium stearate (vegetable), and silica

Directions: Take one capsule twice daily with food or as directed by your healthcare practitioner.

Caution: Not recommended for pregnant or nursing women. If taking medication, consult your healthcare practitioner before use. Keep out of the reach of children.

Formulated to Exclude: Wheat, gluten, soy, animal or dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives.

This product is Gluten Free and Vegetarian.

†Range of 1,400 mg-1575 mg

 Cal Apatite With Magnesium®

Cal Apatite® with Magnesium provides advanced, bioactive support for healthy bone mineralization with microcrystalline hydroxyapatite concentrate (MCHC)--a calcium-rich, bone-derived supplement that provides a full spectrum of highly absorbable macro- and trace minerals, Type 1 collagen protein, the intact portion of bone, and bioactive bone growth factors. Cal Apatite with Magnesium features an exclusive, freeze-dried MCHC that ensures higher levels of intact bone growth factors than other MCHC formulas. This unique formula provides optimized levels of vitamin D and a blend of three forms of magnesium to achieve a 2:1 calcium to magnesium ratio.

  • Features 300 mg per serving of magnesium--an important mineral found primarily in bone tissue and essential for musculoskeletal health.*

  • Provides a 2:1 calcium to magnesium ratio.

Serving Size: 3 Tablets

Ingredient

Amount

Daily Value

Vitamin D (as cholecalciferol)

600 IU 

150% 

Calcium (as MCHC and dicalcium phosphate)

600 mg 

60% 

Phosphorus (as MCHC and dicalcium phosphate)

378 mg 

38% 

Magnesium (as magnesium citrate, magnesium aspartate, and magnesium bis-glycinate+)

300 mg 

75% 

MCHC+

1500 mg 

Other Ingredients: microcrystalline cellulose, croscarmellose sodium, sodium starch glycolate, cellulose, stearic acid (vegetable), silica, and coating (water, hypromellose, medium chain triglycerides, and hydroxypropylcellulose)
Directions: Take three tablets daily or as directed by your healthcare practitioner.
Caution: Keep out of the reach of children.
Formulated to Exclude: Wheat, gluten, corn protein, soy, dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives.
This product is Gluten Free.
†Range of 1,400 mg-1575 mg

 

Ostera®

Promotes Healthy Bone Remodeling in Postmenopausal Women*

Servings Per Container: 60

In a clinical study of postmenopausal women with low estrogen levels, Ostera™—in conjunction with a modified Mediterranean, low glycemic diet and regular exercise—was shown to beneficially influence key markers of bone remodeling more than diet and exercise alone. Bone remodeling is the natural process of healthy breakdown and formation of the bone matrix—the structure where minerals are deposited. This scientifically advanced formula features selective kinase response modulators (SKRMs) in the form of RIAA, as well as the herb berberine, and vitamins D and K to nutritionally support healthy bone remodeling during the aging process. Recommended for use with Cal Apatite®, an advanced bioactive formulation for bone mineralization.*

  • Promotes healthy bone remodeling biomarkers to support bone quality and integrity.*

  • Clinically shown in a study of postmenopausal women with low estrogen levels to:*

    • Beneficially influence key markers of bone remodeling.

    • Positively influence osteocalcin, a key marker of bone remodeling rate.

    • Offer more effectiveness than diet and exercise alone.

  • Features selective kinase response modulators (SKRMs) in the form of RIAA from hops, as well as the herb berberine, and vitamins D and K to nutritionally support healthy bone remodeling during the aging process.*

  • No reported serious adverse effects.

________________________________________________________________________________________________________
Serving Size: 1 Tablet

Ingredient

Amount

Daily Value

Vitamin D (as cholecalciferol)

500 IU 

125% 

Vitamin K (as phytonadione)

500 mcg 

625% 

Berberine HCl (Phellodendron amurense bark extract)

90 mg 

Reduced Iso-Alpha Acids Complex (from hops extract, Humulus lupulus L.)

370 mg 

Other Ingredients: Microcrystalline cellulose, stearic acid (vegetable), croscarmellose sodium, calcium silicate, silica, and coating (water, hypromellose†, medium chain triglycerides, and hydroxypropylcellulose†)

Directions: Take one tablet twice daily, or as directed by your healthcare practitioner.

Warning: Do not use if pregnant or nursing or if taking cyclosporine or anticoagulant medication.

Caution: If taking other medication, consult your healthcare practitioner before use. Keep out of the reach of children.


This product is Gluten Free.

Keep tightly closed in a cool, dry place.

†Range of 1,400 mg-1575 mg
________________________________________________________________________________________________________
FREQUENTLY ASKED QUESTIONS

Q. How does Ostera® compare to other products or approaches?

A. As a nutraceutical, this product is formulated to complement diet and exercise recommendations to promote bone health, but varies significantly from common bone health formulas that contain calcium. This product is intended as a complement to (not a substitute for) supplemental calcium recommendations. Ostera offers an approach for a unique target in postmenopausal bone health support, and may be the only nutritional supplement specifically designed to support healthy bone remodeling.*

Q. How does Ostera® work?

A. This product contains a science-based blend of ingredients to promote healthy bone remodeling, which supports the bone architecture that holds calcium and other minerals. Bone is living tissue, and the remodeling process helps remove old or damaged tissue and build new tissue. This process slows down with age and can also be influenced by estrogen decline in menopause and a subtle increase (associated with age or unhealthy lifestyle patterns) in cytokines that signal various body activities. Cellular studies showed that the RIAA in Ostera acts as a selective kinase (specialized enzyme) response modulator (SKRM) in signaling processes in the body related to bone health. (Balanced kinase signaling helps to maintain healthy function, and SKRMs can enhance "healthy" signals from a targeted dietary plan.) Berberine and vitamins D and K also help nutritionally support healthy bone remodeling during the aging process.*

Q. How long is Ostera® typically recommended?

A. This formula was designed for daily support of healthy bone remodeling--a continual process that influences the quality of bone structure. In a 12-week study at the FMRC, the Ostera program (including a low-glycemic-load diet and regular exercise) was shown to be more effective than diet and exercise alone in positively influencing markers of bone remodeling in postmenopausal women with low estrogen levels. Individual results may vary. Your health care professional may recommend regular follow-up visits to re-evaluate markers of bone health. For best results, follow your health care professional's guidelines.*

Q. Who would benefit from Ostera®?

A. Health care professionals typically recommend this product to postmenopausal women as part of a more comprehensive bone health program, specifically to promote healthy bone remodeling and support the integrity (quality) of the bone matrix (the architecture where minerals are deposited). This product may also be recommended for men or women prior to menopause, where appropriate. This product is not intended as a substitute for bone mineralization (density) support, such as MCHC calcium.*

Q. Why is Ostera® safe?

A. It contains a blend of natural ingredients with an excellent safety profile. Plus, Metagenics' manufacturing facility has 3 certifications for good manufacturing practices to ensure the highest quality. Key active ingredients in this formula were developed through the ExpresSyn Process(r) that sets a new standard in clinical certainty for natural products via demonstrated efficacy, bioavailability, and a high level of predicted safety. Ostera has been clinically reviewed at the FMRC. (This product is not recommended for those taking anticoagulant medications.)

 Black Cohosh Plus®

Relief for Menopausal Mood Changes*

Servings Per Container: 60

Black Cohosh Plus® is a non-phytoestrogen formula designed to relieve menopausal complaints with a mood component. Black cohosh, the primary herb in this formula, is traditionally used to address meno-pausal nervousness, irritability, occasional sleep disturbances, and vasomotor symptoms. Lemon balm and motherwort are traditionally used to help ease tension and support relaxation.*

  • Features black cohosh, an herb traditionally used by women during menopause that is especially popular today in Europe for relief of menopausal symptoms such as:*

    • Hot flushes/night sweats

    • Short menstrual cycles

    • Occasional irritability

    • Mild mood swings

  • Occasional sleep disturbances:

    • Provides lemon balm and motherwort, herbs traditionally used to ease tension and support relaxation.*

Serving Size: 1 Tablet

Ingredient

Amount

Daily Value

Black Cohosh (Actaea racemosa†) Root & Rhizome Extract [standardized

80 mg 

Motherwort (Leonurus cardiaca) Aerial Parts 6.5:1 Extract

100 mg 

Lemon Balm (Melissa officinalis) Leaf 5:1 Extract

50 mg 

Other Ingredients: Microcrystalline cellulose, stearic acid (vegetable), sodium starch glycolate, silica, and coating (water, hypromellose, medium chain triglycerides, and hydroxypropylcellulose)

Directions: Take one tablet twice daily or as directed by your healthcare practitioner.

Warning: Do not use if pregnant or nursing.

Caution: Consult your healthcare practitioner before use if you are taking medication, have breast cancer or a history of breast cancer, or have a liver disorder or develop symptoms of liver trouble. Keep out of the reach of children.

Formulated to Exclude: Wheat, gluten, corn protein, soy, animal or dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives.

This product is Gluten Free and Vegetarian.

Keep tightly closed in a cool, dry place.

†At date of expiration.